载脂蛋白 E ε4 等位基因对纵向认知轨迹的影响依赖于性别和年龄。
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
机构信息
Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
出版信息
Alzheimers Dement. 2019 Dec;15(12):1558-1567. doi: 10.1016/j.jalz.2019.07.011. Epub 2019 Sep 24.
INTRODUCTION
Questions remain about whether apolipoprotein E (APOE)-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains.
METHODS
In sex-stratified analyses, baseline age-dependent associations between APOE-ε4 status and longitudinal cognitive trajectories were examined in cognitively normal Caucasian older adults (631 men, 561 women, baseline age range: 50-93, 6733 assessments).
RESULTS
In men, older baseline age was associated with greater effects of APOE-ε4 on longitudinal decline in memory and executive function, detectible from baseline age of 64 and 68, respectively. In women, older baseline age was associated with greater APOE-ε4 effects on longitudinal decline in attention, detectible at baseline age of 66. No significant APOE-ε4 effects were found for language, visual-spatial ability, or processing speed.
DISCUSSION
Results highlight the importance of considering sex and age when assessing APOE-ε4-associated vulnerability to cognitive decline.
简介
载脂蛋白 E（APOE）-ε4 对认知衰退的影响在男性和女性中是否相似，以及 APOE-ε4 和年龄如何相互作用影响不同认知领域的衰退，这些问题仍未得到解答。
方法
在性别分层分析中，在认知正常的白种老年人中（631 名男性，561 名女性，基线年龄范围：50-93 岁，共进行 6733 次评估），研究了 APOE-ε4 状态与纵向认知轨迹之间随基线年龄变化的关联。
结果
在男性中，较老的基线年龄与 APOE-ε4 对记忆和执行功能的纵向下降的影响更大相关，从基线年龄 64 岁和 68 岁分别可以检测到。在女性中，较老的基线年龄与 APOE-ε4 对注意力的纵向下降的影响更大相关，从基线年龄 66 岁可以检测到。在语言、视觉空间能力或处理速度方面，未发现 APOE-ε4 有显著影响。
讨论
结果强调了在评估 APOE-ε4 与认知衰退相关的脆弱性时，考虑性别和年龄的重要性。
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