Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations.
作者信息
Shimizu Takuya, Kondo Tadakazu, Matsumoto Kana, Hishizawa Masakatsu, Yamashita Kouhei, Takaori-Kondo Akifumi
机构信息
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan.
出版信息
Transpl Infect Dis. 2019 Dec;21(6):e13185. doi: 10.1111/tid.13185. Epub 2019 Oct 15.
We present a patient with virus-associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo-HSCT). Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.
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