老年特应性皮炎患者血液中心血管和动脉粥样硬化标志物增加。
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis.
机构信息
Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.
出版信息
Ann Allergy Asthma Immunol. 2020 Jan;124(1):70-78. doi: 10.1016/j.anai.2019.10.013. Epub 2019 Oct 14.
BACKGROUND
Atopic dermatitis (AD) is associated with increased systemic inflammation and cardiovascular risk. Although previous studies have found increased inflammatory proteins in the blood of patients with AD, detailed comparison among patients with AD of different ages is unavailable.
OBJECTIVE
To characterize the blood proteomic signature of patients with AD as a function of age.
METHODS
We used the OLINK high-throughput proteomic assay to measure serum inflammatory and cardiovascular risk proteins in 71 patients with moderate to severe AD from 3 age groups (18-40 years old [n = 26], 41-60 years old [n = 24], and >60 years old [n = 21]) compared with 37 age-matched controls. Total and allergen-specific serum IgEs were also measured.
RESULTS
When we compared patients with AD from 3 different age groups with their respective controls, we identified a total of 172 differentially expressed proteins. T2 chemokines (CCL13, CCL17) were consistently elevated in patients with AD across all ages (P < .05), whereas T1 (CXCL10) and T17 (KYNU, CCL20) markers incrementally increased with age in both patients with AD and healthy subjects. Elderly patients with AD (>60 years old) exhibited striking upregulation of key proinflammatory proteins, including markers of atherosclerosis (CCL4, CCL7, SORT1), cardiovascular risk (GDF15, MPO, ST2), cell adhesion (CDH3), and apoptosis (FAS; all P < .05) compared with younger patients with AD and age-matched controls. We also found that total and allergen-specific serum IgEs decreased significantly with age in patients with AD (P < .05).
CONCLUSION
Elderly patients with AD had increased levels of systemic inflammatory markers, including those associated with cardiovascular and atherosclerosis risk, which may explain their increased incidence of cardiovascular disease. This finding suggests that older patients with AD may benefit from cardiovascular disease screening and prevention.
背景
特应性皮炎（AD）与全身性炎症增加和心血管风险相关。尽管先前的研究已经发现 AD 患者血液中的炎症蛋白增加，但对于不同年龄 AD 患者之间的详细比较尚不清楚。
目的
描述 AD 患者的血液蛋白质组特征与年龄的关系。
方法
我们使用 OLINK 高通量蛋白质组学检测方法，对 71 名来自 3 个年龄组（18-40 岁 [n=26]、41-60 岁 [n=24]和>60 岁 [n=21]）的中重度 AD 患者和 37 名年龄匹配的对照者的血清炎症和心血管风险蛋白进行了测量。还测量了总血清 IgE 和过敏原特异性 IgE。
结果
当我们将 3 个不同年龄组的 AD 患者与各自的对照者进行比较时，我们共鉴定出 172 个差异表达蛋白。T2 趋化因子（CCL13、CCL17）在所有年龄段的 AD 患者中均持续升高（P<0.05），而 T1（CXCL10）和 T17（KYNU、CCL20）标志物在 AD 患者和健康对照者中均随年龄逐渐增加。老年 AD 患者（>60 岁）与年轻 AD 患者和年龄匹配的对照者相比，表现出关键促炎蛋白的显著上调，包括动脉粥样硬化标志物（CCL4、CCL7、SORT1）、心血管风险标志物（GDF15、MPO、ST2）、细胞黏附标志物（CDH3）和细胞凋亡标志物（FAS；均 P<0.05）。我们还发现 AD 患者的总血清 IgE 和过敏原特异性 IgE 随年龄显著下降（P<0.05）。
结论
老年 AD 患者的全身性炎症标志物水平增加，包括与心血管和动脉粥样硬化风险相关的标志物，这可能解释了他们心血管疾病发病率增加的原因。这一发现表明，年龄较大的 AD 患者可能受益于心血管疾病筛查和预防。
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