一种具有增强的光稳定性的菁染料类光敏剂，用于线粒体靶向光动力疗法。
A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy.
机构信息
Digestive Medicine Center, The second affiliated Hospital of Xuzhou Medical University, Xu Zhou 221000, China.
College of Chemistry, Shandong Normal University, Jinan 250014, China and Department of Light Sources and Illuminating Engineering, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
出版信息
Chem Commun (Camb). 2019 Nov 7;55(90):13542-13545. doi: 10.1039/c9cc06157f.
A cyanine-derivative photosensitizer, CYBF2, was synthesized for photodynamic therapy of cancer. The photosensitizer can be activated by red-light with enhanced photostability compared to traditional cyanine photosensitizers. CYBF2 was able to generate singlet oxygen inside the cell mitochondria, which efficiently resulted in apoptosis of cancer cells.
一种吖啶衍生物类光动力治疗剂 CYBF2 的合成及其性能研究。与传统的吖啶类光敏剂相比，该光动力治疗剂具有更好的光稳定性，可被红光激活。CYBF2 可以在细胞线粒体中产生单线态氧，有效地导致癌细胞凋亡。
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