在宏基因组学时代研究肠道病毒组：挑战与展望。
Studying the gut virome in the metagenomic era: challenges and perspectives.
机构信息
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
出版信息
BMC Biol. 2019 Oct 28;17(1):84. doi: 10.1186/s12915-019-0704-y.
The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems.
人类肠道中栖息着复杂的微生物生态系统，包括细菌和病毒。随着下一代测序技术的兴起，我们对人类肠道常驻细菌的研究取得了突飞猛进的发展，但感染这些细菌的病毒，即噬菌体，仍未得到充分探索。在这篇综述中，我们重点介绍了噬菌体在人类健康中的作用以及研究肠道病毒组（其中噬菌体是主要组成部分）所涉及的技术挑战。最后，我们讨论了从其他生态系统中噬菌体研究中可以学到什么。
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