Wei Shuai, Chelliah Ramachandran, Rubab Momna, Oh Deog-Hwan, Uddin Md Jalal, Ahn Juhee
Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea.
Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Microorganisms. 2019 Nov 17;7(11):570. doi: 10.3390/microorganisms7110570.
The global problem of antibiotic resistance in bacteria is quickly developing in most antibiotics used in hospitals and livestock. Recently, the infections with multi-drug resistant (MDR) bacteria become a major cause of death worldwide. Current antibiotics are not very effective in treating MDR Salmonella infections, which have become a public health threat. Therefore, novel approaches are needed to rapidly detect and effectively control antibiotic-resistant pathogens. Bacteriophages (phages) have seen renewed attention for satisfying those requirements due to their host-specific properties. Therefore, this review aims to discuss the possibility of using phages as a detection tool for recognizing bacterial cell surface receptors and an alternative approach for controlling antibiotic-resistant pathogens in food systems.
细菌对抗生素耐药性这一全球性问题在医院和畜牧业使用的大多数抗生素中迅速发展。最近,多重耐药(MDR)细菌感染已成为全球范围内的主要死亡原因。目前的抗生素在治疗多重耐药沙门氏菌感染方面效果不佳,这种感染已对公共卫生构成威胁。因此,需要新的方法来快速检测并有效控制抗生素耐药病原体。由于噬菌体具有宿主特异性,人们重新关注它们以满足这些需求。因此,本综述旨在探讨将噬菌体用作识别细菌细胞表面受体的检测工具以及控制食品系统中抗生素耐药病原体的替代方法的可能性。