原发性纤毛运动障碍的鼻一氧化氮测量。标准化测试方案技术论文。
Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols.
机构信息
Division of Pediatric Respiratory Medicine, McGill University Health Centre Research Institute, Montreal Children's Hospital, Montreal, Quebec, Canada.
Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
出版信息
Ann Am Thorac Soc. 2020 Feb;17(2):e1-e12. doi: 10.1513/AnnalsATS.201904-347OT.
Nasal nitric oxide concentrations are extremely low in primary ciliary dyskinesia (PCD), and measurement of this nasal gas is recommended as a PCD diagnostic test in cooperative patients aged 5 years and older. However, nasal nitric oxide measurements must be performed with chemiluminescence analyzers using a standardized protocol to ensure proper results, because nasal nitric oxide values can be influenced by various internal and external factors. Repeat nasal nitric oxide testing on separate visits is required to ensure that low diagnostic values are persistent and consistent with PCD. This technical paper presents the standard operating procedures for nasal nitric oxide measurement used by the PCD Foundation Clinical and Research Centers Network at various specialty centers across North America. Adherence to this document ensures reliable nasal nitric oxide testing and high diagnostic accuracy when employed in a population with appropriate clinical phenotypes for PCD.
鼻一氧化氮浓度在原发性纤毛运动障碍（PCD）中极低，建议对 5 岁及以上合作患者进行这种鼻气体测量作为 PCD 的诊断性检测。然而，为确保得到准确的结果，必须使用化学发光分析仪，根据标准化方案进行鼻一氧化氮测量，因为鼻一氧化氮值会受到各种内外因素的影响。需要在不同的就诊时重复鼻一氧化氮检测，以确保低诊断值是持续的，与 PCD 一致。本技术文件介绍了北美各地 PCD 基金会临床和研究中心网络的各个专业中心使用的鼻一氧化氮测量标准操作规程。在具有适当 PCD 临床表型的人群中使用本文件可确保可靠的鼻一氧化氮检测和高诊断准确性。
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