Emerging resistance of genotype in enterococci: A potential menace for therapeutic failure.

OBJECTIVES

Emerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the genotype responsible for vancomycin resistance.

METHODS

A total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC 29212 was used as a quality control strain. The detection of genotypes was accomplished by multiplex PCR assay.

RESULTS

Out of the 147 enterococci, 139 (94.6%) were , and 8 (5.4%) were . Statistically significant associations of urine (p < 0.001), pus (p < 0.001) and wound swabs (p = 0.001) were observed with . A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of found to be VRE with (75%) and (25%) genotypes.

CONCLUSION

The emerging strains of VRE ( and genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option.