细菌膜泡产生减少预示着ST45/USA600耐甲氧西林菌血症患者的死亡率
Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant Bacteremia.
作者信息
Dey Somrita, Gudipati Smitha, Giuliano Christopher, Zervos Marcus J, Monk Jonathan M, Szubin Richard, Jorgensen Sarah C J, Sakoulas George, Berti Andrew D
机构信息
Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI 48201, USA.
Henry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA.
出版信息
Antibiotics (Basel). 2019 Dec 18;9(1):2. doi: 10.3390/antibiotics9010002.
Immune biomarkers can stratify mortality risk in staphylococcal bacteremia. Microbial biomarkers may provide more consistent signals during early infection. We demonstrate that in ST45/USA600 bacteremia, bacterial membrane vesicle production in vitro predicts clinical mortality (773 vs. 116 RFU, survivors vs. decedents, < 0.0001). Using a threshold of 301 relative fluorescence units (RFU), the sensitivity and specificity of the membrane vesicles to predict mortality are 78% and 90%, respectively. This platform is facile, scalable and can be integrated into clinical microbiology lab workflows.
免疫生物标志物可对葡萄球菌血症的死亡风险进行分层。微生物生物标志物在早期感染期间可能提供更一致的信号。我们证明，在ST45/USA600菌血症中，体外细菌膜泡产生可预测临床死亡率（幸存者与死亡者分别为773 vs. 116相对荧光单位，<0.0001）。使用301相对荧光单位（RFU）的阈值，膜泡预测死亡率的敏感性和特异性分别为78%和90%。该平台操作简便、可扩展，且可整合到临床微生物学实验室工作流程中。
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