腹部肥胖儿童生活方式干预后端粒长度与人体测量及血糖变化的关联

Associations of telomere length with anthropometric and glucose changes after a lifestyle intervention in abdominal obese children.

作者信息

Morell-Azanza Lydia, Ojeda-Rodríguez Ana, Azcona-SanJulián Ma Cristina, Zalba Guillermo, Marti Amelia

机构信息

Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; IdiSNA (Navarra Institute for Health Research), Pamplona, Spain.

IdiSNA (Navarra Institute for Health Research), Pamplona, Spain; Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Apr 12;30(4):694-700. doi: 10.1016/j.numecd.2019.12.002. Epub 2019 Dec 10.

DOI:10.1016/j.numecd.2019.12.002

PMID:32007334

Abstract

BACKGROUND AND AIMS

In lifestyle intervention studies, we demonstrated that changes in telomere length (TL) were associated with changes in anthropometric indices. Therefore, our new hypothesis is that TL could be a predictor of changes in anthropometric or metabolic measures in children with abdominal obesity. The aim of the study was to evaluate the association between anthropometric and biochemical measurements with TL before and after an 8-week lifestyle intervention in children with abdominal obesity (7-16 years old).

METHODS AND RESULTS

We assessed anthropometric and biochemical outcomes at baseline and after 8-week lifestyle intervention in 106 children with abdominal obesity (11.30 ± 2.49 years old, 63% girls). TL was measured by monochrome multiplex real-time quantitative PCR. After the lifestyle intervention, anthropometric parameters and glucose metabolism indicators significantly improved in the participants. TL did not change after the intervention in participants. Significant negative correlations between baseline TL and anthropometric measures (BMI, body weight and waist circumference) were observed. Furthermore, baseline TL was a predictor for changes in blood glucose levels after the lifestyle intervention.

CONCLUSIONS

An inverse correlation between TL and obesity traits was observed in children with abdominal obesity. Interestingly, we found that baseline TL could predict changes in blood glucose levels.

CLINICAL TRIAL

NCT03147261. Registered 10 May 2017.

摘要

背景与目的

在生活方式干预研究中，我们证明了端粒长度（TL）的变化与人体测量指标的变化相关。因此，我们的新假设是，TL可能是腹型肥胖儿童人体测量或代谢指标变化的预测因子。本研究的目的是评估腹型肥胖儿童（7 - 16岁）在进行为期8周的生活方式干预前后，人体测量和生化指标与TL之间的关联。

方法与结果

我们对106名腹型肥胖儿童（11.30 ± 2.49岁，63%为女孩）在基线和8周生活方式干预后评估了人体测量和生化指标。通过单色多重实时定量PCR测量TL。生活方式干预后，参与者的人体测量参数和糖代谢指标显著改善。干预后参与者的TL没有变化。观察到基线TL与人体测量指标（BMI、体重和腰围）之间存在显著负相关。此外，基线TL是生活方式干预后血糖水平变化的预测因子。