骨科生物材料：免疫调节的过去与未来
Biomaterials in orthopaedics: the past and future with immune modulation.
作者信息
Im Gun-Il
机构信息
Research Institute for Integrative Regenerative Biomedical Engineering, Dongguk University Ilsan Hospital, 814 Siksa-Dong, Goyang, 410-773 Republic of Korea.
出版信息
Biomater Res. 2020 Feb 4;24:7. doi: 10.1186/s40824-020-0185-7. eCollection 2020.
Abstract
Orthopaedics owes its current status of advanced care to the development of biomaterial science more than any other clinical medical specialty. The purpose of this brief review is to introduce the history and present status of biomaterials in orthopaedic field and cast a perspective on the future use of biomaterials to treat musculoskeletal disorders with particular emphasis on immune modulation. While the biomaterials in orthopaedics started from inert materials to replace the function and structure of hard tissue such as bone and cartilage, regenerative medicine will play a greater role in preventing the traumatic loss of tissues, as well as in the earlier stages of diseases. The understanding and modulation of immune response to biomaterials will further lead to the better incorporation of implants into host tissue or the near-perfect regeneration of host tissue.
摘要
与其他临床医学专科相比，骨科学目前先进的护理水平更多地归功于生物材料科学的发展。本简要综述的目的是介绍生物材料在骨科领域的历史和现状，并展望生物材料在治疗肌肉骨骼疾病方面的未来应用，特别强调免疫调节。虽然骨科中的生物材料始于惰性材料，用于替代骨骼和软骨等硬组织的功能和结构，但再生医学将在预防组织创伤性损失以及疾病早期阶段发挥更大作用。对生物材料免疫反应的理解和调节将进一步使植入物更好地融入宿主组织，或实现宿主组织的近乎完美再生。
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