饮食和身体活动干预对结直肠癌幸存者一般和癌症特异性健康相关生活质量、焦虑和抑郁的影响：一项随机对照试验。
Effects of dietary and physical activity interventions on generic and cancer-specific health-related quality of life, anxiety, and depression in colorectal cancer survivors: a randomized controlled trial.
机构信息
School of Nursing, The University of Hong Kong, 4/F William M.W. Mong Block, 21 Sassoon Road, Pok Fu Lam, Hong Kong.
Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.
出版信息
J Cancer Surviv. 2020 Aug;14(4):424-433. doi: 10.1007/s11764-020-00864-0. Epub 2020 Feb 18.
PURPOSE
To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors.
METHODS
Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects.
RESULTS
Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months.
CONCLUSIONS
Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors.
TRIAL REGISTRATION
The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824).
IMPLICATIONS FOR CANCER SURVIVORS
CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.
目的
评估饮食和身体活动（PA）干预对中国成年结直肠癌（CRC）幸存者一般和癌症特异性生活质量（QoL）、焦虑和抑郁水平的影响。
方法
223 名在完成主要癌症治疗后 1 年内的成年 CRC 幸存者，按照 2（饮食与常规护理）×2（PA 与常规护理）析因设计，随机分为接受饮食、PA 或联合干预或常规护理 12 个月。使用中文版 12 项简明健康调查问卷（SF-12）和癌症治疗功能评估-结直肠癌（FACT-C）量表分别评估一般和癌症特异性 QoL。在基线、6、12、18 和 24 个月时使用医院焦虑和抑郁量表评估焦虑和抑郁。线性混合模型用于检验干预效果。
结果
接受饮食干预的参与者在 12 个月时 SF-6D 效用评分（平均差值 0.042，95%CI 0.03 至 0.081）、癌症特异性 QoL 评分（平均差值 3.09，95%CI 0.13 至 6.04）和抑郁水平（P=0.015）方面均有显著改善。仅接受 PA 干预的参与者在 6 个月时 SF-6D 效用指数（平均差值 0.039，95%CI 0.002 至 0.077）和身体功能（平均差值 2.85，95%CI 1.00 至 4.70）方面有显著改善。
结论
饮食干预改善了 CRC 幸存者的一般和癌症特异性 QoL 和抑郁。
试验注册
该研究于 2012 年 10 月 17 日在 ClinicalTrials.gov 前瞻性注册（NCT01708824）。
对癌症幸存者的影响
CRC 幸存者可以从饮食干预中受益，减轻抑郁情绪，改善整体健康相关的 QoL。
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