Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, Ohio.
J Surg Res. 2020 Jul;251:6-15. doi: 10.1016/j.jss.2019.12.050. Epub 2020 Feb 22.
The devastating effects of the opioid epidemic are well documented. We implemented a surgeon/pharmacist opioid reduction initiative at an academic medical center that incorporated multimodal pain therapy in an attempt to reduce total inpatient opioids prescribed. We hypothesized that less opioids would be used postoperatively without affecting pain scores or length of stay.
This single-center observational cohort analysis included patients admitted to the acute general surgical service and had one of 10 emergent general surgical (nontrauma) procedures. Patients who underwent surgery before the opioid reduction initiative were compared with patients who underwent surgery postinitiative. The primary objective was to evaluate differences in daily oral morphine equivalents and average pain scores in patients before and after implementation of the surgeon/pharmacist initiative.
Eighty-three patients in the preopioid reduction initiative group and 92 patients in the postopioid reduction initiative group met inclusion criteria. Oral morphine equivalents were significantly different at 24 h before discharge when comparing across both year (P = 0.032) and number of procedures (P = 0.013). Our results showed decreased opioid utilization in the postopioid reduction initiative group on all observed postoperative days with unaffected pain scores.
An opioid reduction initiative showed promise in lowering the number of opioids used during inpatient admission without affecting pain scores in emergent general surgical procedures. This initiative can be easily reproduced at other institutions to help combat the opioid epidemic.
阿片类药物泛滥的破坏性影响已有充分记录。我们在一家学术医疗中心实施了一项外科医生/药剂师阿片类药物减量计划,该计划纳入了多模式疼痛疗法,试图减少住院患者开具的阿片类药物总量。我们假设在不影响疼痛评分或住院时间的情况下,术后阿片类药物的使用量会减少。
这项单中心观察性队列分析纳入了入住急性普通外科病房的患者,且接受了 10 种紧急普通外科(非创伤)手术之一。将在阿片类药物减量计划实施前接受手术的患者与实施后接受手术的患者进行比较。主要目的是评估外科医生/药剂师计划实施前后患者每日口服吗啡等效物和平均疼痛评分的差异。
在阿片类药物减量计划实施前组有 83 例患者,实施后组有 92 例患者符合纳入标准。在比较两年(P=0.032)和手术次数(P=0.013)时,出院前 24 小时的口服吗啡等效物明显不同。我们的结果显示,在术后所有观察日,阿片类药物减量计划实施后组的阿片类药物使用量减少,而疼痛评分不受影响。
阿片类药物减量计划在降低紧急普通外科手术患者住院期间阿片类药物使用量方面显示出了前景,而不影响疼痛评分。这项计划可以在其他机构轻松复制,以帮助应对阿片类药物泛滥。