黄病毒包膜蛋白糖基化：对病毒感染和发病机制的影响。
Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis.
机构信息
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
出版信息
J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00104-20.
Abstract
Flaviviruses encode one, two, or no -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication. Envelope protein glycosylation has been identified as a virulence determinant for multiple flaviviruses, but the mechanisms by which glycosylation mediates pathogenesis remain unclear. In this Gem, we summarize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and pathogenesis.
摘要
黄病毒在其包膜蛋白上编码一个、两个或无连接的糖基化位点。糖基化会影响病毒与细胞表面附着因子的相互作用，也可能影响病毒粒子的稳定性和病毒复制。包膜蛋白糖基化已被确定为多种黄病毒的毒力决定因素，但糖基化介导发病机制的机制尚不清楚。在这篇综述中，我们总结了黄病毒包膜蛋白糖基化及其对病毒感染和发病机制影响的最新知识。
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