外周血白细胞端粒 G 尾长度检测乳腺癌的诊断性能。
Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer.
机构信息
Surgical Oncology, Division of Radiation Biology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
出版信息
Cancer Sci. 2020 May;111(5):1856-1861. doi: 10.1111/cas.14378. Epub 2020 Apr 6.
The telomere G-tail (G-tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G-tail length of breast cancer (BC) patients and cancer-free individuals and evaluated the association between the G-tail length and the presence of BC. A significant shortening of the median G-tail length was observed in BC patients compared with cancer-free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G-tail length might be a potential biomarker for BC detection.
端粒 G 尾（G-tail）在维持染色体稳定性方面发挥着重要作用。本研究评估了乳腺癌（BC）患者和无癌症个体的白细胞 G 尾长度，并评估了 G 尾长度与 BC 存在之间的关联。与无癌症个体相比，BC 患者的中位 G 尾长度明显缩短，并且在 BC 的早期阶段就已经发现。我们的研究表明，白细胞 G 尾长度可能是 BC 检测的潜在生物标志物。
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