工程化生殖组织。
Engineered reproductive tissues.
机构信息
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
Nat Biomed Eng. 2020 Apr;4(4):381-393. doi: 10.1038/s41551-020-0525-x. Epub 2020 Apr 6.
Abstract
Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients.
摘要
正在开发工程化的男性和女性仿生生殖组织，作为自主的体外单位或作为集成的多器官体外系统，以支持生殖细胞和胚胎功能，并显示特征性的内分泌表型模式，如 28 天的人类排卵周期。在这篇综述中，我们总结了工程化生殖组织如何促进生殖生物学的研究，并概述了制造工程化生殖组织的策略，这些组织最终可能允许恢复患者的生殖能力。
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本文引用的文献
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ACS Biomater Sci Eng. 2016 Oct 10;2(10):1817-1826. doi: 10.1021/acsbiomaterials.6b00031. Epub 2016 May 6.
2
Proteomic analyses of decellularized porcine ovaries identified new matrisome proteins and spatial differences across and within ovarian compartments.
Sci Rep. 2019 Dec 27;9(1):20001. doi: 10.1038/s41598-019-56454-3.
3
Optimizing The Cell Seeding Protocol to Human Decellularized Ovarian Scaffold: Application of Dynamic System for Bio-Engineering.
Cell J. 2020 Jul;22(2):227-235. doi: 10.22074/cellj.2020.6604. Epub 2019 Oct 14.
4
Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix.
Int J Mol Sci. 2019 Nov 3;20(21):5476. doi: 10.3390/ijms20215476.
5
Generation of Multicellular Human Primary Endometrial Organoids.
J Vis Exp. 2019 Oct 4(152). doi: 10.3791/60384.
6
Generation of Porcine Testicular Organoids with Testis Specific Architecture using Microwell Culture.
J Vis Exp. 2019 Oct 3(152). doi: 10.3791/60387.
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Placenta-on-a-Chip: In Vitro Study of Caffeine Transport across Placental Barrier Using Liquid Chromatography Mass Spectrometry.
Glob Chall. 2019 Feb 18;3(3):1800112. doi: 10.1002/gch2.201800112. eCollection 2019 Mar.
8
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