小白菊内酯在脂肪细胞分化过程中通过激活Nrf2/Keap1信号通路抑制脂质积累。
Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation.
作者信息
Kim Chae Young, Kang Bobin, Hong Jungil, Choi Hyeon-Son
机构信息
1Department of Public Health Sciences, Korea University, Seoul, 07249 Republic of Korea.
2Department of Food Science and Technology, College of Natural Science, Seoul Women's University, Seoul, 139-774 Republic of Korea.
出版信息
Food Sci Biotechnol. 2019 Aug 26;29(3):431-440. doi: 10.1007/s10068-019-00672-y. eCollection 2020 Mar.
The effects of parthenolide (PL), a sesquiterpene lactone obtained from feverfew plant, on lipid accumulation and signaling pathway in adipocytes were investigated. PL significantly inhibited lipid accumulation and adipogenic factors during adipogenesis. In particular, PL exerted its inhibitory effects in early adipogenic stage by regulating the early adipogenic factors. In addition, PL regulated the expression of adipokines; leptin, retinol binding protein, and resistin mRNAs were downregulated, whereas adiponectin gene expression was increased. Furthermore, PL significantly reduced intracellular reactive oxygen species (ROS) production during adipogenesis. This PL-mediated regulation of ROS production was associated with the regulation of nuclear factor erythroid 2-related factor (Nrf2)-kelch-like ECH-associated protein 1 (Keap1) pathway. PL effectively increased the abundance of Nrf2 and its target proteins, heme oxygenase-1 (HO-1) and NADPH dehydrogenase 1 (NQO1), by promoting the nuclear translocation of Nrf2, indicating that PL-mediated anti-adipogenic effects are associated with the Nrf2/Keap1 pathway.
研究了从小白菊植物中提取的倍半萜内酯小白菊内酯（PL）对脂肪细胞脂质积累和信号通路的影响。PL在脂肪生成过程中显著抑制脂质积累和脂肪生成因子。特别是，PL通过调节早期脂肪生成因子在早期脂肪生成阶段发挥其抑制作用。此外，PL调节脂肪因子的表达；瘦素、视黄醇结合蛋白和抵抗素的mRNA水平下调，而脂联素基因表达增加。此外，PL在脂肪生成过程中显著降低细胞内活性氧（ROS）的产生。这种PL介导的ROS产生调节与核因子红细胞2相关因子（Nrf2）- Kelch样ECH相关蛋白1（Keap1）途径的调节有关。PL通过促进Nrf2的核转位有效增加了Nrf2及其靶蛋白血红素加氧酶-1（HO-1）和NADPH脱氢酶1（NQO1）的丰度，表明PL介导的抗脂肪生成作用与Nrf2/Keap1途径有关。
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