CYP2C19 基因型预测的酶活性对海马体积、焦虑和抑郁的影响。
Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.
机构信息
Department of Neuroscience, University of Calgary, Calgary, AB, Canada.
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia.
出版信息
Psychiatry Res. 2020 Jun;288:112984. doi: 10.1016/j.psychres.2020.112984. Epub 2020 Apr 13.
Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.
细胞色素 P450 C19（CYP2C19）代谢外源性和内源性化合物。尽管 CYP2C19 在肝脏中高度表达，但在生命早期也在大脑中表达。先前的人类和动物研究将 CYP2C19 基因型预测的酶活性与海马体积、抑郁症状和焦虑样行为联系起来。我们在一个没有精神或神经病史的 386 名白种人成年人的普通社区样本中研究了这些有前途的关联。与先前的发现相反，CYP2C19 基因型预测的酶活性与海马体积、抑郁和焦虑症状无关。CYP2C19 频率和/或研究方法的研究差异可能解释了这一差异。
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