[年龄、合并症及肾素-血管紧张素-醛固酮系统在新型冠状病毒肺炎中的作用。血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂的影响]
[Role of age, comorbidity and renin- angiotensin-aldosterone system in COVID-19. Effects of ACE inhibitors and angiotensin receptor blockers].
作者信息
Mareev Yu V, Mareev V Yu
机构信息
National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky Per. 10, Bldg. 3, Moscow 101990.
Medical Scientific-Educational Canter of MSU n. a. M. V. Lomonosov, Moscow.
出版信息
Kardiologiia. 2020 Apr 8;60(4):4-9. doi: 10.18087/cardio.2020.4.n1122.
The review addressed the relationship of coronavirus disease 2019 (COVID-19) with functioning of the renin-angiotensin-aldosterone axis and the causes for unfavorable prognosis depending on patients' age and comorbidities. The authors discussed in detail potential effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists on the risk of infection and the course of COVID-2019 as well as the effect of SARS-COV2 virus on the cardiovascular system.
该综述探讨了2019冠状病毒病（COVID-19）与肾素-血管紧张素-醛固酮轴功能的关系，以及取决于患者年龄和合并症的不良预后原因。作者详细讨论了血管紧张素转换酶抑制剂和血管紧张素II 1型受体拮抗剂对感染风险和COVID-19病程的潜在影响，以及严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒对心血管系统的影响。
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