鉴定与胶质瘤预后相关的枢纽基因。
Identification of hub genes related to prognosis in glioma.
机构信息
Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu 241001, Anhui, People's Republic of China.
Central Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui, People's Republic of China.
出版信息
Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20193377.
Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research value. Conjoint analysis on the GSE16011 dataset in the Gene Expression Omnibus (GEO) database and the 'Messenger RNA Expression Microarray of Diffuse Gliomas and Controls' dataset and 'RNA sequencing of Diffuse Gliomas' dataset in the Chinese Glioma Genome Atlas (CGGA) database is carried out in the study. The weighted correlation network analysis (WGCNA) was used to carry out co-expression analysis on the GSE16011. Finally, 24 genes significantly related to grade and prognosis were obtained. In addition, there is no report about CACNG2, JPH3, TUBB6 (tubulin β 6 class V), NRSN1, FAM19A2, NALCN, CDH18, GNAL on glioma.
脑胶质瘤是一种常见的中枢神经系统恶性肿瘤，具有高度侵袭性。本研究旨在鉴定在脑胶质瘤发生发展中起重要作用的基因，并揭示其潜在的研究价值。该研究对基因表达综合数据库（GEO）中的 GSE16011 数据集、“弥漫性脑胶质瘤及对照的信使 RNA 表达微阵列”数据集和中国脑胶质瘤基因组图谱（CGGA）数据库中的“弥漫性脑胶质瘤的 RNA 测序”数据集进行了联合分析。采用加权相关网络分析（WGCNA）对 GSE16011 进行共表达分析。最后，得到了 24 个与分级和预后显著相关的基因。此外，在脑胶质瘤中尚未有关于 CACNG2、JPH3、TUBB6（微管β 6 类 V）、NRSN1、FAM19A2、NALCN、CDH18、GNAL 的报道。
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