miRNAs 在胰腺癌中的预后价值：一项荟萃分析。
Prognostic value of microRNAs in pancreatic cancer: a meta-analysis.
机构信息
, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining, Shandong, China.
出版信息
Aging (Albany NY). 2020 May 18;12(10):9380-9404. doi: 10.18632/aging.103214.
BACKGROUND
The prognostic impact of microRNA (miRNA) expression levels in pancreatic cancer (PC) has been estimated for years, but the outcomes are controversial and heterogeneous. Therefore, we comprehensively reviewed the evidence collected on miRNA expression in PC to determine this effect.
RESULTS
PC patients with high miR-21 (HR=2.61, 95%CI=1.68-4.04), miR-451a (HR=2.23, 95%CI=1.23-4.04) or miR-1290 (HR=1.43, 95%CI=1.04-1.95) levels in blood had significantly poorer OS (P<0.05). Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR-17-5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05).
CONCLUSIONS
In summary, blood miR-21, miR-451a, miR-1290 and tissue miR-10b, miR-17-5p, miR-21, miR-23a, miR-29c, miR-126, miR-155, miR-203, miR-218, miR-221, miR-222 had significant prognostic value.
METHODS
We searched PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews to recognize eligible studies, and 57 studies comprising 5445 PC patients and 15 miRNAs were included to evaluate the associations between miRNA expression levels and overall survival (OS) up to June 1, 2019. Summary hazard ratios (HR) with 95% confidence intervals (CI) were calculated to assess the effect.
背景
多年来，人们一直在评估微小 RNA（miRNA）表达水平对胰腺癌（PC）的预后影响，但结果存在争议且具有异质性。因此，我们全面回顾了 miRNA 在 PC 中表达的证据，以确定这种影响。
结果
血液中 miR-21（HR=2.61，95%CI=1.68-4.04）、miR-451a（HR=2.23，95%CI=1.23-4.04）或 miR-1290（HR=1.43，95%CI=1.04-1.95）水平较高的 PC 患者的总生存期（OS）明显较差（P<0.05）。此外，组织中 miR-10b（HR=1.73，95%CI=1.09-2.76）、miR-17-5p（HR=1.91，95%CI=1.30-2.80）、miR-21（HR=1.90，95%CI=1.61-2.25）、miR-23a（HR=2.18，95%CI=1.52-3.13）、miR-155（HR=2.22，95%CI=1.27-3.88）、miR-203（HR=1.65，95%CI=1.14-2.40）、miR-221（HR=1.72，95%CI=1.08-2.74）、miR-222 水平（HR=1.72，95%CI=1.02-2.91）或组织中 miR-29c（HR=1.39，95%CI=1.08-1.79）、miR-126（HR=1.55，95%CI=1.23-1.95）、miR-218（HR=2.62，95%CI=1.41-4.88）水平较高的 PC 患者的 OS 明显缩短（P<0.05）。
结论
总之，血液中的 miR-21、miR-451a、miR-1290 和组织中的 miR-10b、miR-17-5p、miR-21、miR-23a、miR-29c、miR-126、miR-155、miR-203、miR-218、miR-221、miR-222 具有显著的预后价值。
方法
我们检索了 PubMed、EMBASE、Web of Science 和 Cochrane 系统评价数据库，以识别合格的研究，共纳入了 57 项研究，包含 5445 名 PC 患者和 15 种 miRNA，以评估 miRNA 表达水平与总生存期（OS）之间的相关性，截至 2019 年 6 月 1 日。采用综合风险比（HR）及其 95%置信区间（CI）来评估这种影响。
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