早发性头颈癌患者的家庭成员及配偶的家族癌症风险

Familial cancer risk in family members and spouses of patients with early-onset head and neck cancer.

作者信息

Mroueh Rayan, Tanskanen Tomas, Haapaniemi Aaro, Salo Tuula, Malila Nea, Mäkitie Antti, Pitkäniemi Janne

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.

Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland.

出版信息

Head Neck. 2020 Sep;42(9):2524-2532. doi: 10.1002/hed.26282. Epub 2020 May 30.

DOI:10.1002/hed.26282

PMID:32472619

Abstract

BACKGROUND

Reported patterns of familial aggregation of head and neck cancer (HNC) vary greatly, with many studies hampered by the limited number of subjects.

METHODS

Altogether 923 early-onset (≤40 years old) HNC probands, their first-degree relatives, spouses, and siblings' offspring were ascertained. Cumulative risk and standardized incidence ratios (SIRs) were estimated.

RESULTS

Of all early-onset HNC families, only 21 (2.3%) had familial HNC cancers at any age and less than five familial early onset HNC cancers among first-degree relatives. The cumulative risk of HNC for siblings by age 60 (0.52%) was at population level (0.33%). No increased familial risk of early-onset HNC could be discerned in family members (SIR 2.68, 95% CI 0.32-9.68 for first-degree relatives).

CONCLUSIONS

Our study indicates that the cumulative and relative familial risk of early-onset HNC is modest in the Finnish population and, at most, only a minor proportion of early-onset HNCs are due solely to inherited genetic mutations.

摘要

背景

头颈部癌（HNC）家族聚集模式的报道差异很大，许多研究因样本量有限而受到阻碍。

方法

共确定了923名早发型（≤40岁）HNC先证者、他们的一级亲属、配偶以及兄弟姐妹的后代。估计累积风险和标准化发病率比（SIR）。

结果

在所有早发型HNC家族中，只有21个（2.3%）在任何年龄患有家族性HNC癌症，且一级亲属中家族性早发型HNC癌症少于5例。60岁时兄弟姐妹患HNC的累积风险（0.52%）处于人群水平（0.33%）。在家庭成员中未发现早发型HNC家族风险增加（一级亲属的SIR为2.68，95%CI为0.32 - 9.68）。