与生物膜形成相关的葡萄球菌疫苗抗原。
Staphylococcal Vaccine Antigens related to biofilm formation.
作者信息
Mirzaei Bahman, Babaei Ryhaneh, Valinejad Sina
机构信息
Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences , Sari, Iran.
Department of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Science , Zanjan, Iran.
出版信息
Hum Vaccin Immunother. 2021 Jan 2;17(1):293-303. doi: 10.1080/21645515.2020.1767449. Epub 2020 Jun 4.
Abstract
The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for , in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.
摘要
作为医院感染常见病因的多重耐药（MDR）菌株的数量和频率有所增加，尤其是对于与器械相关的感染而言，部分原因就在于此。相关细菌基因向抗生素耐药性的转变以及免疫逃逸能力提高了这些细菌产生的生物膜的可持续性。生物膜的形成和变化已被认为是预防或治疗葡萄球菌感染的一个靶点。因此，本研究通过数据库检索回顾了候选葡萄球菌疫苗的发展情况，并评估了生物膜中细菌成分的免疫原性和功效概况。文献表明，使用常见的葡萄球菌疫苗抗原和多价疫苗应能进一步提高疫苗效力。
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