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创伤性三叉神经神经病手术治疗的益处:回顾性分析。

The benefit of surgical management in post-traumatic trigeminal neuropathy: a retrospective analysis.

机构信息

OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium; Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium; Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

出版信息

Int J Oral Maxillofac Surg. 2021 Jan;50(1):132-138. doi: 10.1016/j.ijom.2020.05.004. Epub 2020 Jun 3.

Abstract

Post-traumatic trigeminal neuropathy (PTTN) is a known complication of common oral and maxillofacial procedures. The burden on the patient and society is often underestimated. This retrospective study included 29 patients with PTTN who underwent surgical treatment. Symptoms were differentiated, pre- and postoperatively, into neuropathic discomfort and loss of perceptive function. Clinical and patient-reported outcomes were recorded. The Brief Pain Inventory questionnaire was completed at the last follow-up. The effect of different variables was evaluated through subgroup analysis. The mean time interval between injury and surgery was 19 weeks. Overall, 20 patients (69%) showed improvement during a mean follow-up of 49 months. Neuropathic pain decreased in most patients (13/18; 72%) and two patients became pain-free. However, 16 patients reported persistent pain on the Brief Pain Inventory questionnaire. Medication use decreased postoperatively. Subgroup analysis showed a positive association between improvement and male sex (Fisher's exact test, P=0.033), and between improvement and the buccal fat nerve wrapping procedure (Fisher's exact test, P=0.02). In conclusion, surgery showed substantial benefit in the treatment of PTTN, even when neuropathic pain was present. The effect of different variables and the potential of buccal fat nerve wrapping should be evaluated further in future research.

摘要

创伤后三叉神经痛(PTTN)是常见口腔颌面手术的已知并发症。患者和社会的负担往往被低估。本回顾性研究纳入了 29 例接受手术治疗的 PTTN 患者。症状在术前和术后分为神经病理性不适和知觉功能丧失。记录了临床和患者报告的结果。在最后一次随访时完成简短疼痛问卷。通过亚组分析评估不同变量的影响。损伤与手术之间的平均时间间隔为 19 周。总体而言,20 名患者(69%)在平均 49 个月的随访中显示出改善。大多数患者的神经病理性疼痛减轻(13/18;72%),两名患者疼痛消失。然而,16 名患者在简短疼痛问卷中报告持续疼痛。术后用药减少。亚组分析显示,改善与男性性别之间存在正相关(Fisher 确切检验,P=0.033),与颊脂神经包裹术之间存在正相关(Fisher 确切检验,P=0.02)。总之,即使存在神经病理性疼痛,手术在 PTTN 的治疗中也显示出了显著的益处。未来的研究应进一步评估不同变量的影响和颊脂神经包裹术的潜力。

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