肿瘤抗原的交叉呈递受树突状细胞亚群之间囊泡的突触传递调控。
Cross-Presentation of Tumor Antigens Is Ruled by Synaptic Transfer of Vesicles among Dendritic Cell Subsets.
机构信息
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA.
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA; Parker Institute of Cancer Immunotherapy, San Francisco, CA 94129, USA.
出版信息
Cancer Cell. 2020 Jun 8;37(6):751-753. doi: 10.1016/j.ccell.2020.05.013.
Migratory dendritic cells (DCs) in tumors transport antigens and share them with lymph node resident DCs through cross-presentation. In this issue of Cancer Cell, Ruhland et al. demonstrate that transport and transfer of tumor antigens in vesicles is a dominant pathway to load resident DCs for presentation to T cells.
肿瘤中的迁移树突状细胞 (DCs) 通过交叉呈递将抗原运送到淋巴结内的常驻 DCs 并与其分享。在本期 Cancer Cell 杂志上，Ruhland 等人证明，通过小泡运输和转移肿瘤抗原是一种将肿瘤抗原加载到常驻 DCs 以呈递给 T 细胞的主要途径。
Zotero 插件