新型冠状病毒肺炎与牙周病之间嗜中性粒细胞胞外陷阱形成的有趣共性。
The intriguing commonality of NETosis between COVID-19 & Periodontal disease.
作者信息
Gupta Shipra, Sahni Vaibhav
机构信息
Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Panjab University, Chandigarh, India.
出版信息
Med Hypotheses. 2020 Nov;144:109968. doi: 10.1016/j.mehy.2020.109968. Epub 2020 Jun 7.
NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation of autoimmune mechanisms. Such pathophysiology finds evidence in both Periodontal disease and COVID-19. Coupled with impaired removal, NETs have been implicated in both these disease forms to promote a state of inflammation and be a source of constant harm to the tissues involved. This potentially forms groundwork to implicate Periodontal disease as predisposing towards adverse COVID-19 related outcomes.
中性粒细胞胞外陷阱形成（NETosis）作为一种细胞死亡的替代形式，是由适当预激活的中性粒细胞形成类似网状的染色质解聚产物，作为对旨在控制和消除病原体的刺激的反应。在某些情况下，它直接或通过激活自身免疫机制以旁观者损伤的形式造成的危害大于益处。这种病理生理学在牙周病和新冠肺炎中都有证据。再加上清除受损，NETs在这两种疾病形式中都被认为会促进炎症状态，并对相关组织造成持续损害。这可能为将牙周病视为导致不良新冠肺炎相关结果的易患因素奠定基础。
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