结核病与冠心病风险：系统评价和荟萃分析。
Tuberculosis and risk of coronary heart disease: A systematic review and meta-analysis.
机构信息
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Indian J Tuberc. 2020 Apr;67(2):182-188. doi: 10.1016/j.ijtb.2020.01.008. Epub 2020 Jan 24.
BACKGROUND
Increased risk of coronary heart disease has been observed in several chronic inflammatory disorders, including chronic infection. However, data on the association between tuberculosis and risk of coronary heart disease are limited.
METHODOLOGY
This systematic review and meta-analysis identified all cohort studies that compared the risk of coronary heart disease among patients with tuberculosis versus individuals without tuberculosis and summarized their results together. Literature search was independently conducted by two investigators using MEDLINE and EMBASE database up to August 2019. Point estimates and standard errors from each study were pooled together using the generic inverse variance method of DerSimonian and Laird.
RESULTS
A total of four cohort studies met the eligibility criteria and were included into the meta-analysis. The pooled analysis found that patients with tuberculosis have an increased risk of developing coronary heart disease with the pooled risk ratio of 1.76 (95% CI, 1.05-2.95; I of 97%).
CONCLUSION
A significantly increased risk of coronary heart disease among patients with tuberculosis was demonstrated by the current study.
背景
几种慢性炎症性疾病，包括慢性感染，都会观察到冠心病风险增加。然而，关于结核病与冠心病风险之间关系的数据有限。
方法
本系统评价和荟萃分析确定了所有比较结核病患者与无结核病个体冠心病风险的队列研究，并对其结果进行了汇总。两名研究人员独立使用 MEDLINE 和 EMBASE 数据库进行文献检索，检索时间截至 2019 年 8 月。使用 DerSimonian 和 Laird 的通用倒数方差法汇总每个研究的点估计值和标准误差。
结果
共有 4 项队列研究符合纳入标准，并纳入荟萃分析。汇总分析发现，结核病患者发生冠心病的风险增加，汇总风险比为 1.76（95%CI，1.05-2.95；I²为 97%）。
结论
本研究表明，结核病患者发生冠心病的风险显著增加。
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