骨肉瘤中的微小RNA特征、微小RNA的生物信息学分析、微小RNA模拟物和拮抗剂以及微小RNA治疗
MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma.
作者信息
Otoukesh Babak, Abbasi Mehdi, Gorgani Habib-O-Lah, Farahini Hossein, Moghtadaei Mehdi, Boddouhi Bahram, Kaghazian Peyman, Hosseinzadeh Shayan, Alaee Atefe
机构信息
Orthopedic Surgery Fellowship in Département Hospitalo-Universitaire MAMUTH « Maladies musculo-squelettiques et innovations thérapeutiques » , Université Pierre et Marie-Curie, Sorbonne Université, Paris, France.
Department of Orthopedic Surgery, Bone and Joint Reconstruction Research Center, Iran University of Medical Science, Postal code : 1445613131 Tehran, Iran.
出版信息
Cancer Cell Int. 2020 Jun 17;20:254. doi: 10.1186/s12935-020-01342-4. eCollection 2020.
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
讨论了参与骨肉瘤（OS）关键信号通路和侵袭性表型的微小RNA（miRNA），包括PI3K/AKT/MTOR、MTOR和RAF-1信号传导、与肿瘤抑制因子P53相关的miRNA、与NOTCH相关的miRNA、miRNA -15/16簇、与凋亡相关的miRNA、与侵袭转移相关的miRNA以及与14Q32相关的miRNA簇。此外，我们还讨论了对包括miRNA（即肿瘤抑制性miRNA和致癌miRNA）在内的靶向治疗的见解。利用生物信息学工具，还描绘了所有与骨肉瘤相关的miRNA及其靶标的相互作用网络。
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