微小 RNA hsa-miR-30c-5p 和 hsa-miR-138-1 在肾细胞癌中的表达。
Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma.
机构信息
Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine, Kyiv 03143, Ukraine.
Institute of Urology, National Academy of Medical Sciences of Ukraine, Kyiv 04053, Ukraine.
出版信息
Exp Oncol. 2020 Jun;42(2):115-119. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-2.14632.
AIM
To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers.
MATERIALS AND METHODS
The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor.
RESULTS
We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients.
CONCLUSIONS
A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.
目的
分析人源微小 RNA-30c-5p（hsa-miR-30c-5p）和 hsa-miR-138-1 在肾细胞癌患者肿瘤组织中的表达水平，以确定它们是否可作为诊断标志物。
材料与方法
比较配对的肾肿瘤组织和肿瘤旁常规正常组织中 hsa-miR-30c-5p 和 hsa-miR-138-1 的相对表达。
结果
我们发现，即使在早期癌症病例中，肿瘤组织中的 miR-30c-5p 和 miR-138-1 水平也显著降低。此外，与 Fuhrman 分级 G2 相比，Fuhrman 分级 G3+G4 的肾细胞癌中 miR-138-1 的表达水平更低。然而，我们未发现 miR-30c-5p 和 miR-138-1 在肿瘤中的表达与肾细胞癌患者的主要临床和病理特征之间存在相关性。
结论
肾细胞癌中 hsa-miR-30c-5p 和 hsa-miR-138-1 表达水平的显著降低表明进一步研究这些标志物可能的诊断效用具有可行性。
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