眼部淋巴瘤的组织病理学特征和安阿伯分期。
Histopathological Features and Ann Arbor Stage in Periocular Lymphoma.
机构信息
Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany
Institute of Pathology, University Medical Center Rostock, Rostock, Germany.
出版信息
In Vivo. 2020 Jul-Aug;34(4):1965-1974. doi: 10.21873/invivo.11993.
BACKGROUND
To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL).
PATIENTS AND METHODS
A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018.
RESULTS
OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048).
CONCLUSION
Our data suggest that clinicopathological features such as Ann Arbor stage influence survival.
背景
评估眼附属器淋巴瘤（OAL）的生物数据、症状/体征、淋巴瘤类型、定位、分期水平、治疗选择和结果。
患者和方法
对 1998 年至 2018 年期间在单中心接受治疗的 56 例 OAL 患者进行回顾性分析。
结果
OAL 累及眼眶占 44.6%，结膜占 32.1%，泪器占 14.3%，眼睑占 8.93%。边缘区 B 细胞淋巴瘤（EMZL）占 60.7%，滤泡性淋巴瘤（FL）占 21.4%，弥漫性大 B 细胞淋巴瘤占 7.14%，套细胞淋巴瘤占 5.36%，慢性淋巴细胞白血病占 5.36%。76%的患者无复发。EMZL 和 FL 的总生存率明显优于其他淋巴瘤类型（p=0.002）。Ann Arbor 分期为 IE 的患者预后明显优于分期高于 IE 的患者（p=0.048）。
结论
我们的数据表明，临床病理特征如 Ann Arbor 分期影响生存。
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