新型冠状病毒肺炎患者中由严重急性呼吸综合征冠状病毒2引起的急性肾损伤：一项综合综述
Acute Kidney Injury by SARS-CoV-2 virus in patients with COVID-19: an integrative review.
作者信息
Moitinho Matheus Santos, Belasco Angélica Gonçalves da Silva, Barbosa Dulce Aparecida, Fonseca Cassiane Dezoti da
机构信息
Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
出版信息
Rev Bras Enferm. 2020;73 Suppl 2:e20200354. doi: 10.1590/0034-7167-2020-0354. Epub 2020 Jul 10.
OBJECTIVE
to assess scientific evidence on SARS-CoV-2 Acute Kidney Injury in patients with COVID-19.
METHODS
an integrative review, with adoption of PICO strategy and classification of the level of evidence, carried out on April 10, 2020 in the PubMed database, of articles available between December 2019 and April 2020.
RESULTS
the sample consisted of six original, five observational and one experimental articles. Observational studies addressed the clinical findings of patients with COVID-19 and association between kidney damage, infection, and morbidity-mortality.
CONCLUSION
the studies addressed the mechanism of intracellular infection of SARS-CoV-2, its cytopathic effects on kidney cells and incidence of acute kidney injury in patients infected with SARS-CoV-2. Acute kidney injury is associated with increased mortality and morbidity in these patients. This review realizes the need for new research that can mention kidney care to patients with COVID-19.
目的
评估2019冠状病毒病（COVID-19）患者中新型冠状病毒2型（SARS-CoV-2）所致急性肾损伤的科学证据。
方法
于2020年4月10日在PubMed数据库中采用PICO策略并对证据水平进行分类，对2019年12月至2020年4月间可获取的文章进行综合综述。
结果
样本包括6篇原创文章、5篇观察性文章和1篇实验性文章。观察性研究探讨了COVID-19患者的临床发现以及肾损伤、感染与发病-死亡率之间的关联。
结论
这些研究探讨了SARS-CoV-2的细胞内感染机制、其对肾细胞的细胞病变效应以及SARS-CoV-2感染患者急性肾损伤的发生率。急性肾损伤与这些患者的死亡率和发病率增加相关。本综述认识到需要开展新的研究，以便能提及对COVID-19患者的肾脏护理。
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