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人体测量学在皮肤和眼部黑色素瘤的免疫治疗中的应用。

Anthropometry in the immunotherapy of cutaneous and ocular melanomas.

机构信息

OncoHelp Oncology Center, Timișoara, Romania.

Department of Ophthalmology, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.

出版信息

Rom J Ophthalmol. 2020 Apr-Jun;64(2):190-194.

Abstract

The height of the adult individual is a balance of the expression of some genetic factors (especially the Y-M 170 haplotype of the Y chromosome) and the environment (nutrition and morbidity during childhood). Higher height is associated with a low risk of developing coronary heart disease, hypertension, gastroesophageal reflux, diaphragmatic hernia, but with a higher risk for atrial fibrillation, venous thromboembolism, intervertebral disc pathology, vasculitis and cancer. The research consisted of a retrospective observational study on patients who received immunotherapy (IT) with nivolumab for cutaneous and ocular melanoma neoplasms. We intended to highlight the associations between the duration of immunotherapy and sex profiles, age, anthropometric data (height, weight). Even though the number of available cases was relatively small (42), an inverse association between the body mass index of the subjects and the duration of immunotherapy could be proved, a more expressed association in case of male patients.

摘要

成年人的身高是一些遗传因素(尤其是 Y 染色体上的 Y-M170 单倍型)和环境(儿童期的营养和发病情况)表达的平衡。较高的身高与患冠心病、高血压、胃食管反流、膈疝的风险较低相关,但与房颤、静脉血栓栓塞、椎间盘病变、血管炎和癌症的风险较高相关。这项研究是对接受纳武利尤单抗免疫治疗(IT)治疗皮肤和眼部黑色素瘤肿瘤的患者进行的回顾性观察性研究。我们旨在强调免疫治疗的持续时间与性别特征、年龄、人体测量数据(身高、体重)之间的关联。尽管可用病例数相对较少(42 例),但我们可以证明,在 subjects 中,体重指数与免疫治疗的持续时间呈负相关,而在男性患者中,这种相关性更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d379/7339699/672d44d08ab4/RomJOphthalmol-64-190-g001.jpg

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