新疆哈萨克族人群总胆红素和间接胆红素含量与代谢综合征的关系。
Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang.
机构信息
Department of Public Health, Shihezi University School of Medicine, Shihezi, 832000, Xinjiang, China.
The First Affiliated Hospital of Shihezi University Medical College, Shihezi, 832000, Xinjiang, China.
出版信息
BMC Endocr Disord. 2020 Jul 22;20(1):110. doi: 10.1186/s12902-020-00563-y.
BACKGROUND
Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published.
METHODS
Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria.
RESULTS
The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31-0.71), 0.53 (0.35-0.79), and 0.48 (0.32-0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32-0.72), 0.54(0.36-0.81), and 0.52 (0.35-0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS.
CONCLUSION
Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China.
背景
一些研究表明，胆红素水平较高是代谢综合征（MS）的保护因素，而转氨酶水平较高是 MS 的危险因素。然而，现有的研究结果并不一致，且发表的队列研究较少。
方法
采用前瞻性队列研究，选取中国新疆的 565 名哈萨克族人为研究对象。根据研究对象的基线血清胆红素和转氨酶水平将其分为四分位，并分析这些值与 MS 发病率的关系。MS 的定义基于联合临时声明（JIS）诊断标准。
结果
研究对象的平均随访时间为 5.72 年。MS 的累积发病率为 36.11%（565 例中有 204 例），发病率密度为 63.10/1000人年。多变量 Cox 回归分析表明，总胆红素（TBIL）和间接胆红素（IBIL）水平与 MS 的发生呈负相关。与最低四分位（Q1）相比，TBIL 水平在 Q2-Q4 四分位的 MS 风险比分别为：0.47（0.31-0.71）、0.53（0.35-0.79）和 0.48（0.32-0.72），而 IBIL 水平在 Q2-Q4 四分位的 MS 风险比分别为：0.48（0.32-0.72）、0.54（0.36-0.81）和 0.52（0.35-0.77），均在 95%置信区间内。然而，未发现转氨酶水平与 MS 发病率之间存在关系。
结论
在中国哈萨克族人群中，血清 TBIL 和 IBIL 水平与 MS 的发病率呈负相关。
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