促卵泡生成素及其受体在人类代谢性疾病和癌症中的作用。
Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer.
作者信息
Sun Di, Bai Mingzhu, Jiang Yanyu, Hu Meiyan, Wu Sufang, Zheng Wenxin, Zhang Zhenbo
机构信息
Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University Shanghai 200080, China.
Department of Obstetrics and Gynecology, Shanghai General Hospital Shanghai 200080, China.
出版信息
Am J Transl Res. 2020 Jul 15;12(7):3116-3132. eCollection 2020.
Follicle stimulating hormone (FSH) and its receptor (FSHR) play an important role in human metabolic diseases and cancer. Evidence showed that FSHR is not only distributed in ovary and testis but also in other cells or organs such as osteoclast, adipocytes, liver, pituitary cancer and so forth. Moreover, FSH is associated with lipogenesis, inflammation, insulin sensitivity, thermogenesis, skeletal metabolism, osteogenesis and ovarian cancer, all of which have been confirmed closely related to metabolic diseases or metabolic-related cancer. Therefore, FSH and FSHR may be potential therapeutic targets for metabolic diseases and metabolic-related cancer. Epidemiological researches revealed close relationship between FSH/FSHR and metabolic diseases or cancer. Experimental studies elucidated the underlying mechanism both in vivo and in vitro. We reviewed the recent researches and present an integrated framework of FSH/FSHR and metabolic diseases and cancer, which provides potential targets for the treatments of metabolic diseases and cancer.
促卵泡激素（FSH）及其受体（FSHR）在人类代谢性疾病和癌症中发挥着重要作用。证据表明，FSHR不仅分布于卵巢和睾丸，还存在于其他细胞或器官中，如破骨细胞、脂肪细胞、肝脏、垂体癌等。此外，FSH与脂肪生成、炎症、胰岛素敏感性、产热、骨骼代谢、骨生成和卵巢癌相关，所有这些均已被证实与代谢性疾病或代谢相关癌症密切相关。因此，FSH和FSHR可能是代谢性疾病和代谢相关癌症的潜在治疗靶点。流行病学研究揭示了FSH/FSHR与代谢性疾病或癌症之间的密切关系。实验研究阐明了体内和体外的潜在机制。我们回顾了近期的研究，并提出了一个关于FSH/FSHR与代谢性疾病和癌症的综合框架，为代谢性疾病和癌症的治疗提供了潜在靶点。
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