使用羰基光催化剂从α-酮酸生成酰基自由基：光氧化还原催化合成酮
Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones.
作者信息
Zhu Da-Liang, Wu Qi, Young David James, Wang Hao, Ren Zhi-Gang, Li Hong-Xi
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
College of Engineering, Information Technology and Environment, Charles Darwin University, Darwin, Northern Territory 0909, Australia.
出版信息
Org Lett. 2020 Sep 4;22(17):6832-6837. doi: 10.1021/acs.orglett.0c02351. Epub 2020 Aug 18.
Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.
在可见光照射下，使用廉价且市售的2-氯噻吨-9-酮作为光氧化还原催化剂，从α-酮酸中产生了酰基自由基。这些活性物种通过联吡啶稳定的Ni(II)催化剂加成到烯烃上或与芳基卤化物偶联，从而能够轻松获得各种酮类。这种可靠、原子经济且环保的方法与多种官能团兼容。
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