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Mechanisms of direct replication restart at stressed replisomes.

作者信息

Conti Brooke A, Smogorzewska Agata

机构信息

Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA.

Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA.

出版信息

DNA Repair (Amst). 2020 Nov;95:102947. doi: 10.1016/j.dnarep.2020.102947. Epub 2020 Aug 16.

Abstract
摘要

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Regulation of translesion DNA synthesis in mammalian cells.
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change.
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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells.
Mol Cell. 2020 Feb 6;77(3):461-474.e9. doi: 10.1016/j.molcel.2019.10.008. Epub 2019 Oct 29.
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BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress.
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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators.
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Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
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RIF1 promotes replication fork protection and efficient restart to maintain genome stability.
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