2019冠状病毒病大流行及封锁措施对侵袭性脑膜炎球菌病的影响
Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease.
作者信息
Taha Muhamed-Kheir, Deghmane Ala-Eddine
机构信息
Invasive Bacterial Infections Unit and the National Reference Centre for Meningococci and Haemophilus influenzae, Paris, France.
出版信息
BMC Res Notes. 2020 Aug 27;13(1):399. doi: 10.1186/s13104-020-05241-9.
OBJECTIVE
Few data are available on the association between SARS-CoV-2 and secondary bacterial infections. Such an association was described for flu and invasive meningococcal disease (IMD). We aimed exploring such a correlation between COVID-19 and IMD as well as the impact of the lockdown on IMD.
RESULTS
We compared IMD cases received at the French National Reference Centre for meningococci and Haemophilus influenzae that are sent as part of the mandatory reporting of IMD. We compared these data during the period 01 January-15 May 2020 to those from the same period in 2018 and 2019. IMD cases that were associated with respiratory presentations significantly increased in 2020 compared to 2018 (P = 0.029) and 2019 (P = 0.002), involved elderly and were due to unusual isolates. However, IMD cases due to hyperinvasive isolates decreased during the lockdown. Enhancing IMD surveillance and anti-meningococcal vaccination in elderly should be addressed.
目的
关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与继发性细菌感染之间的关联，可用数据较少。流感与侵袭性脑膜炎球菌病（IMD）之间存在这样一种关联。我们旨在探索2019冠状病毒病（COVID-19）与IMD之间的这种相关性以及封锁措施对IMD的影响。
结果
我们比较了法国国家脑膜炎球菌和流感嗜血杆菌参考中心接收的作为IMD强制报告一部分的IMD病例。我们将2020年1月1日至5月15日期间的这些数据与2018年和2019年同期的数据进行了比较。与呼吸道表现相关的IMD病例在2020年比2018年（P = 0.029）和2019年（P = 0.002）显著增加，涉及老年人且由不常见的分离株引起。然而，在封锁期间，由高侵袭性分离株引起的IMD病例有所减少。应加强对老年人的IMD监测和抗脑膜炎球菌疫苗接种。
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