金刚烷胺可诱导角膜上皮内沉积。
Amantadine can induce intra-epithelial deposition in the cornea.
作者信息
Yoshinaka Asayo, Chikama Taiichiro, Kiuchi Yoshiaki
机构信息
Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, 1-9-6 Sendamachi, Naka-ku, Hiroshima-shi, Hiroshima, 730-0052, Japan.
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima, 734-8551, Japan.
出版信息
Am J Ophthalmol Case Rep. 2020 Aug 5;19:100852. doi: 10.1016/j.ajoc.2020.100852. eCollection 2020 Sep.
PURPOSE
Amantadine has been reported to cause various corneal complications, such as superficial punctate keratitis, corneal endothelial dysfunction, and corneal edema. However, there have been no reports of amantadine-induced deposits in the corneal epithelium. Here, we describe the first case with amantadine-induced deposits in the corneal epithelium proved by confocal biomicroscopy.
OBSERVATIONS
An 81-year-old woman presented with impaired vision in both eyes. She had been treated with amantadine for 9 years. Corrected visual acuity was 0.8 in both eyes. Furthermore, both eyes showed opacities in the corneal epithelial corneal layer. On confocal biomicroscopy, there were highly reflective deposits in corneal epithelial cells. There were no pathological findings in the stroma and endothelium. Two months after discontinuation of amantadine, corneal opacities disappeared, and visual acuity was 1.0 in both eyes.
CONCLUSIONS
Administration of amantadine can cause deposits in corneal epithelial cells.
目的
据报道，金刚烷胺可引起多种角膜并发症，如浅层点状角膜炎、角膜内皮功能障碍和角膜水肿。然而，尚无金刚烷胺引起角膜上皮沉积的报道。在此，我们描述了首例经共焦显微镜证实的金刚烷胺引起角膜上皮沉积的病例。
观察结果
一名81岁女性出现双眼视力受损。她接受金刚烷胺治疗已9年。双眼矫正视力均为0.8。此外，双眼角膜上皮层均有混浊。共焦显微镜检查显示，角膜上皮细胞中有高反射性沉积物。基质和内皮未发现病理改变。停用金刚烷胺两个月后，角膜混浊消失，双眼视力均为1.0。
结论
服用金刚烷胺可导致角膜上皮细胞出现沉积物。
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