柔软生物材料及其对细胞功能的影响。
Soft biological materials and their impact on cell function.
作者信息
Levental Ilya, Georges Penelope C, Janmey Paul A
机构信息
Department of Bioengineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA and Departments of Physiology and Physics and Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA.
出版信息
Soft Matter. 2007 Feb 14;3(3):299-306. doi: 10.1039/b610522j.
Most organs and biological tissues are soft viscoelastic materials with elastic moduli ranging from on the order of 100 Pa for the brain to 100 000 Pa for soft cartilage. Biocompatible synthetic materials already have many applications, but combining chemical compatibility with physiologically appropriate mechanical properties will increase their potential for use both as implants and as substrates for tissue engineering. Understanding and controlling mechanical properties, specifically softness, is important for appropriate physiological function in numerous contexts. The mechanical properties of the substrate on which, or within which, cells are placed can have as large an impact as chemical stimuli on cell morphology, differentiation, motility, and commitment to live or die.
大多数器官和生物组织都是柔软的粘弹性材料，其弹性模量范围从大脑的约100帕斯卡到软骨的100000帕斯卡。生物相容性合成材料已经有许多应用，但将化学相容性与生理上合适的机械性能相结合，将增加它们作为植入物和组织工程支架的应用潜力。理解和控制机械性能，特别是柔软度，在许多情况下对于适当的生理功能很重要。细胞所处或所在的基质的机械性能对细胞形态、分化、运动以及生存或死亡的决定的影响可能与化学刺激一样大。
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