自然杀伤细胞在结直肠癌中的功能的系统范围评价综述。
A systematic scoping review on natural killer cell function in colorectal cancer.
机构信息
Surgical Services, HRMC, John Hunter Hospital, Locked Bag 1, New Lambton, Newcastle, NSW, 2310, Australia.
Western Hospital, Gordon Street, Melbourne, 3000, Australia.
出版信息
Cancer Immunol Immunother. 2021 Mar;70(3):597-606. doi: 10.1007/s00262-020-02721-6. Epub 2020 Sep 11.
PURPOSE
Natural Killer (NK) cells are a vital part of immune surveillance and have been implicated in colorectal cancer development and prognosis. This systematic review aims to distil the literature on NK cells as it relates to colorectal cancer.
METHODS
All published studies over 10 years relating to NK cells and colorectal cancer were reviewed. All studies publishing in English, searchable via pubmed or through reference review and reporting directly on the nature or function of NK cells in colorectal cancer patients were included. Outcomes were determined as alterations or new information regarding NK cells in colorectal cancer patients.
RESULTS
Natural killer cells may be implicated in the development of colorectal cancer and may play a role in prognostication of the disease. NK cells are altered by the treatment (both surgical and medical) of colorectal cancer and it seems likely that they will also be a target for manipulation to improve colorectal cancer survival.
CONCLUSIONS
NK cell morphology and function are significantly affected by the development of colorectal cancer. Observation of NK cell changes may lead to earlier detection and better prognostication in colorectal cancer. Further study is needed into immunological manipulation of NK cells which may lead to improved colorectal cancer survival.
目的
自然杀伤 (NK) 细胞是免疫监视的重要组成部分，与结直肠癌的发生和预后有关。本系统评价旨在总结 NK 细胞与结直肠癌相关的文献。
方法
综述了 10 年来所有与 NK 细胞和结直肠癌相关的已发表研究。所有发表在英文期刊上、可通过 pubmed 检索或通过参考文献回顾检索、并直接报告 NK 细胞在结直肠癌患者中的性质或功能的研究均被纳入。研究结果确定为 NK 细胞在结直肠癌患者中的变化或新信息。
结果
NK 细胞可能参与了结直肠癌的发生，并且可能在该疾病的预后中起作用。NK 细胞受到结直肠癌治疗（包括手术和药物治疗）的影响，因此它们很可能成为改善结直肠癌生存的操作靶点。
结论
NK 细胞的形态和功能受结直肠癌发展的显著影响。观察 NK 细胞的变化可能导致结直肠癌的早期检测和更好的预后。需要进一步研究免疫调节 NK 细胞，这可能会提高结直肠癌的生存率。
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