维生素 D 摄入与华盛顿高地-因伍德哥伦比亚老龄化项目（WHICAP）中的痴呆风险相关。
Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
机构信息
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Department of Neurology, Penn State Milton S. Hershey Medical Center, Hershey, PA, 17033.
出版信息
Alzheimers Dement. 2020 Oct;16(10):1393-1401. doi: 10.1002/alz.12096. Epub 2020 Sep 13.
INTRODUCTION
Low vitamin D intake and low vitamin D circulating levels have been associated with increased risk for dementia. We aimed to examine the association between vitamin D intake and dementia in a multiethnic cohort.
METHODS
A longitudinal study of 1759 non-demented older (≥65 years) participants of the Washington Heights-Inwood Columbia Aging Project with follow-up visits and completed a food frequency questionnaire. Dementia was diagnosed by consensus using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. Cox hazard regression was performed.
RESULTS
During a mean follow-up of 5.8 years, 329 participants developed dementia. Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54-0.97, P = .030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-ε4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking.
DISCUSSION
Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort.
简介
维生素 D 摄入不足和循环水平较低与痴呆风险增加有关。我们旨在研究多民族队列中维生素 D 摄入与痴呆之间的关系。
方法
对华盛顿高地-因伍德哥伦比亚老龄化项目的 1759 名无痴呆的老年人（≥65 岁）进行了一项纵向研究，这些老年人接受了随访并完成了食物频率问卷。通过使用《精神障碍诊断与统计手册》第四版（DSM-IV）标准进行共识诊断来确定痴呆。进行 Cox 风险回归。
结果
在平均 5.8 年的随访期间，有 329 名参与者患上了痴呆症。与摄入最低 tertile 食物来源维生素 D 的参与者相比，摄入最高 tertile 食物来源维生素 D 的参与者患痴呆症的风险降低（风险比 [HR] 0.72，95%置信区间 [CI] 0.54-0.97，P =.030），调整了年龄、性别、种族/民族、教育、载脂蛋白 E (APOE)-ε4、身体活动、地中海饮食 (MeDI) 评分、收入、抑郁、高血压、糖尿病、心血管疾病和吸烟等因素。
讨论
在多民族队列中，较高的维生素 D 摄入与痴呆风险降低有关。
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