巨噬细胞生物学与心血管疾病
Macrophage Biology in Cardiovascular Diseases.
机构信息
Division of Vascular and Endovascular Surgery, Department of Surgery, University of Wisconsin, Madison.
出版信息
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):e77-e81. doi: 10.1161/ATVBAHA.120.313584. Epub 2020 Oct 15.
Abstract
Macrophages have a key functional role in the pathogenesis of various cardiovascular diseases, such as atherosclerosis and aortic aneurysms. Their accumulation within the vessel wall leads to sustained local inflammatory responses characterized by secretion of chemokines, cytokines, and matrix protein degrading enzymes. Here, we summarize some recent findings on macrophage contribution to cardiovascular disease. We focus on the origin, survival/death, and phenotypic switching of macrophages within vessel walls.
摘要
巨噬细胞在各种心血管疾病（如动脉粥样硬化和主动脉瘤）的发病机制中具有关键的功能作用。它们在血管壁内的积累导致持续的局部炎症反应，其特征是趋化因子、细胞因子和基质蛋白降解酶的分泌。在这里，我们总结了一些关于巨噬细胞对心血管疾病贡献的最新发现。我们重点介绍了血管壁内巨噬细胞的起源、存活/死亡和表型转换。
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