信使核糖核酸转录、翻译与发育性认知和行为障碍中的缺陷
MRNA Transcription, Translation, and Defects in Developmental Cognitive and Behavioral Disorders.
作者信息
Smith Moyra
机构信息
Department of Pediatrics, University of California, Irvine, Irvine, CA, United States.
出版信息
Front Mol Biosci. 2020 Sep 25;7:577710. doi: 10.3389/fmolb.2020.577710. eCollection 2020.
Abstract
The growth of expertise in molecular techniques, their application to clinical evaluations, and the establishment of databases with molecular genetic information has led to greater insights into the roles of molecular processes related to gene expression in neurodevelopment and functioning. The goal of this review is to examine new insights into messenger RNA transcription, translation, and cellular protein synthesis and the relevance of genetically determined alterations in these processes in neurodevelopmental, cognitive, and behavioral disorders.
摘要
分子技术专业知识的增长、其在临床评估中的应用以及包含分子遗传信息的数据库的建立，使人们对与基因表达相关的分子过程在神经发育和功能中的作用有了更深入的了解。本综述的目的是探讨信使核糖核酸转录、翻译和细胞蛋白质合成方面的新见解，以及这些过程中基因决定的改变在神经发育、认知和行为障碍中的相关性。
相似文献
1
MRNA Transcription, Translation, and Defects in Developmental Cognitive and Behavioral Disorders.
Front Mol Biosci. 2020 Sep 25;7:577710. doi: 10.3389/fmolb.2020.577710. eCollection 2020.
2
Dysregulation of Neurite Outgrowth and Cell Migration in Autism and Other Neurodevelopmental Disorders.
Adv Neurobiol. 2020;25:109-153. doi: 10.1007/978-3-030-45493-7_5.
3
Dysregulated Translation in Neurodevelopmental Disorders: An Overview of Autism-Risk Genes Involved in Translation.
Dev Neurobiol. 2019 Jan;79(1):60-74. doi: 10.1002/dneu.22653. Epub 2018 Nov 28.
4
The behavioral neurogenetics of fragile X syndrome: analyzing gene-brain-behavior relationships in child developmental psychopathologies.
Dev Psychopathol. 2003 Fall;15(4):927-68. doi: 10.1017/s0954579403000464.
5
Dissecting the genetic basis of comorbid epilepsy phenotypes in neurodevelopmental disorders.
Genome Med. 2019 Oct 25;11(1):65. doi: 10.1186/s13073-019-0678-y.
6
Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and neuropsychiatric disorder models.
Bioessays. 2014 Sep;36(9):872-83. doi: 10.1002/bies.201400087. Epub 2014 Jul 28.
7
Cognitive rehabilitation with neurodevelopmental disorder: A systematic review.
NeuroRehabilitation. 2017;41(4):707-719. doi: 10.3233/NRE-172146.
8
Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases.
J Mol Neurosci. 2017 Mar;61(3):379-384. doi: 10.1007/s12031-016-0872-y. Epub 2016 Dec 26.
9
Maintenance of Transcription-Translation Coupling by Elongation Factor P.
mBio. 2016 Sep 13;7(5):e01373-16. doi: 10.1128/mBio.01373-16.
10
Sleep EEG oscillations in neurodevelopmental disorders without intellectual disabilities.
Sleep Med Rev. 2020 Feb;49:101224. doi: 10.1016/j.smrv.2019.101224. Epub 2019 Oct 30.
引用本文的文献
1
A comprehensive review of mycotoxins, their toxicity, and innovative detoxification methods.
Toxicol Rep. 2025 Feb 7;14:101952. doi: 10.1016/j.toxrep.2025.101952. eCollection 2025 Jun.
2
DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing.
Nucleic Acids Res. 2024 Oct 14;52(18):e89. doi: 10.1093/nar/gkae765.
本文引用的文献
1
Transcript expression-aware annotation improves rare variant interpretation.
Nature. 2020 May;581(7809):452-458. doi: 10.1038/s41586-020-2329-2. Epub 2020 May 27.
2
Ribosome and Translational Control in Stem Cells.
Cells. 2020 Feb 21;9(2):497. doi: 10.3390/cells9020497.
3
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Cell. 2020 Feb 6;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036. Epub 2020 Jan 23.
4
Predicting the impact of sodium channel mutations in human brain disease.
Epilepsia. 2019 Dec;60 Suppl 3(Suppl 3):S8-S16. doi: 10.1111/epi.14724.
5
Regulation of gene expression by cis-acting long non-coding RNAs.
Nat Rev Genet. 2020 Feb;21(2):102-117. doi: 10.1038/s41576-019-0184-5. Epub 2019 Nov 15.
6
Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3.
Nat Commun. 2019 Oct 29;10(1):4919. doi: 10.1038/s41467-019-12763-9.
7
Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2.
Nat Commun. 2019 Oct 29;10(1):4920. doi: 10.1038/s41467-019-12671-y.
8
Pathogenic Variants in NUP214 Cause "Plugged" Nuclear Pore Channels and Acute Febrile Encephalopathy.
Am J Hum Genet. 2019 Jul 3;105(1):48-64. doi: 10.1016/j.ajhg.2019.05.003. Epub 2019 Jun 6.
9
Long-range enhancer-promoter contacts in gene expression control.
Nat Rev Genet. 2019 Aug;20(8):437-455. doi: 10.1038/s41576-019-0128-0.
10
tRNA Metabolism and Neurodevelopmental Disorders.
Annu Rev Genomics Hum Genet. 2019 Aug 31;20:359-387. doi: 10.1146/annurev-genom-083118-015334. Epub 2019 May 13.
Zotero 插件