手术对犬游离和总 25 羟维生素 D 浓度的影响。
Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs.
机构信息
Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Roslin, Midlothian, UK.
Nationwide Specialist Laboratories, Unit 2 Sawston Park, Cambridge, Cambridgeshire, UK.
出版信息
J Vet Intern Med. 2020 Nov;34(6):2617-2621. doi: 10.1111/jvim.15933. Epub 2020 Oct 14.
BACKGROUND
It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.
OBJECTIVES
Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.
ANIMALS
Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).
METHODS
A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR.
RESULTS
Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37).
CONCLUSION AND CLINICAL IMPORTANCE
This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.
背景
目前尚不清楚低总 25（OH）D 浓度是疾病的原因还是结果。为了填补这一知识空白，需要进行研究来测量游离和总 25（OH）D 在炎症过程中的演变和消退期间的浓度。
目的
狗前十字韧带手术后血清总游离 25（OH）D 浓度会短暂下降。
动物
17 只患有自发性前十字韧带断裂（CCLR）的犬。
方法
对 17 只接受手术治疗的 CCLR 犬进行了一项纵向队列研究，测量手术前 1 天、手术后 1 天和 60 天的血清总游离 25（OH）D、总钙、肌酐、白蛋白、磷酸盐、C 反应蛋白和血浆离子钙浓度。
结果
手术前的中位血清总 25（OH）D 浓度（80.3 nmol/L [范围，43.5-137.3]）在手术后立即显著下降；（术后 1 天 64.8 nmol/L [范围，36.3-116.5]，P < 0.005），然后在术后 60 天增加至与术前浓度无显著差异（中位数 78.0 nmol/L [范围，24.2-115.8]，P = 0.14）。相比之下，手术前的中位游离 25（OH）D 浓度（7.6 pg/mL [范围，3.8-12.2]）在手术后立即显著升高（9.2 pg/mL [范围，5.2-15.7]，P < 0.05），然后在术后 60 天下降至与术前浓度无显著差异（中位数 6.2 pg/mL [范围，4.0-15.8]，P = 0.37）。
结论和临床意义
本研究揭示了评估狗接受择期手术后维生素 D 状态的困难。
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