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COVID-19 大流行期间腹膜透析的可靠性和成功率。

The reliability and success of peritoneal dialysis during the COVID-19 pandemic.

机构信息

Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Gazi University, Ankara, Turkey.

Department of Nephrology, University of Health Sciences, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.

出版信息

Semin Dial. 2021 Mar;34(2):147-156. doi: 10.1111/sdi.12940. Epub 2020 Nov 19.

Abstract

We evaluated the symptoms, changes in laboratory findings during the novel coronavirus disease (COVID-19) pandemic, and the effect of depression in patients with peritoneal dialysis (PD). This is an observational and cross-sectional study. All patients were asked to fill the clinical assessment form and Beck depression and anxiety inventory. Also, the last two laboratory evaluations during this period were examined. A total of 123 patients performing PD were included. None of the patients were diagnosed with COVID-19. In the total study population, parathyroid hormone (PTH), serum albumin, phosphorus and ferritin levels significantly elevated at the end of 97 ± 31 days. PTH and phosphorus levels remained stable in remote monitoring automated PD (RM-APD) group (p = 0.4 and p = 0.5), they tended to increase in continuous ambulatory PD group and significantly increased in automated PD group (p = 0.09 and p = 0.01 for PTH and p = 0.06 and p = 0.001 for phosphorus, respectively). Moderate to severe depression was associated with dyspnoea, weight gain more than 5 kg, fatigue, palpitation and increased anxiety. PD is a reliable and successful form of dialysis and can be safely administered even if hospital access is restricted. Also, RM-APD may be a better choice because of providing more stable bone-mineral metabolism. Moreover, evaluating depression and anxiety is essential for the accurate clinical assessment.

摘要

我们评估了在新型冠状病毒病(COVID-19)大流行期间的症状、实验室检查结果的变化,以及抑郁对腹膜透析(PD)患者的影响。这是一项观察性的横断面研究。所有患者均被要求填写临床评估表和贝克抑郁和焦虑量表。同时,还检查了在此期间的最后两次实验室评估。共纳入 123 名接受 PD 治疗的患者。所有患者均未被诊断为 COVID-19。在总研究人群中,甲状旁腺激素(PTH)、血清白蛋白、磷和铁蛋白水平在 97±31 天末显著升高。在远程监测自动化 PD(RM-APD)组中,PTH 和磷水平保持稳定(p=0.4 和 p=0.5),在持续流动 PD 组中呈升高趋势,在自动化 PD 组中显著升高(PTH 分别为 p=0.09 和 p=0.01,磷分别为 p=0.06 和 p=0.001)。中重度抑郁与呼吸困难、体重增加超过 5kg、疲劳、心悸和焦虑增加有关。PD 是一种可靠且成功的透析方式,即使限制住院治疗,也可以安全进行。此外,由于提供更稳定的骨矿物质代谢,RM-APD 可能是更好的选择。此外,评估抑郁和焦虑对于准确的临床评估至关重要。

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