泰国对 SARS-CoV-2 的基因组监测显示，存在混合输入的人群、本地谱系的扩张以及具有截断 ORF7a 的病毒。
Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a.
机构信息
COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
出版信息
Virus Res. 2021 Jan 15;292:198233. doi: 10.1016/j.virusres.2020.198233. Epub 2020 Nov 21.
Coronavirus Disease 2019 (COVID-19) is a global public health threat. Genomic surveillance of SARS-CoV-2 was implemented in March of 2020 at a major diagnostic hub in Bangkok, Thailand. Several virus lineages supposedly originated in many countries were found, and a Thai-specific lineage, designated A/Thai-1, has expanded to be predominant in Thailand. A virus sample in the SARS-CoV-2 A/Thai-1 lineage contains a frame-shift deletion at ORF7a, encoding a putative host antagonizing factor of the virus.
2019 年冠状病毒病（COVID-19）是全球公共卫生威胁。2020 年 3 月，在泰国曼谷的一个主要诊断中心实施了对 SARS-CoV-2 的基因组监测。发现了几种据称起源于多个国家的病毒谱系，并且一种泰国特有的谱系，被指定为 A/Thai-1，已经在泰国占据主导地位。在 SARS-CoV-2 A/Thai-1 谱系的病毒样本中，ORF7a 编码一个假定的病毒宿主拮抗因子，存在框移缺失。
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