月见草多酚提取物抑制人恶性胸膜间皮瘤细胞的侵袭特性。

Polyphenol Extract from Evening Primrose () Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells.

机构信息

Department of Structural Biology, Medical University of Lodz, Zeligowskiego 7/9 Str., 90-752 Lodz, Poland.

Department of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8 Str., 92-215 Lodz, Poland.

出版信息

Biomolecules. 2020 Nov 19;10(11):1574. doi: 10.3390/biom10111574.

DOI:10.3390/biom10111574

PMID:33228230

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7699585/

Abstract

Extracts from the defatted evening primrose ( Hudziok) seeds are the source of a range of stable polyphenolic compounds, including ellagic acid, gallic acid, and catechin. Our studies evaluate, for the first time, the influence of evening primrose isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness and frequently noted chemoresistance limit its treatment schemes and it is characterized by low prognostic features. Here, we demonstrate that EPE inhibited MPM growth in a dose-dependent manner in cells with increased invasion properties. Moreover, EPE treatment resulted in cell cycle arrest in the G2/M phase and increased apoptosis in invasive MPM cell lines. Additionally, EPE strongly limited invasion and MMP-7 secretion in MPM cancer cells. Our original data provide evidence about the potential anti-invasive effects of EPE in MPM therapy treatment.

摘要

月见草脱脂提取物是一系列稳定多酚化合物的来源，包括鞣花酸、没食子酸和儿茶素。我们的研究首次评估了月见草异丙醇提取物 (EPE) 对恶性胸膜间皮瘤 (MPM) 细胞的影响。MPM 很少被诊断出来，其高度侵袭性和经常被注意到的化疗耐药性限制了其治疗方案，其特征是预后不良。在这里，我们证明 EPE 以剂量依赖的方式抑制具有侵袭性增加的 MPM 细胞的生长。此外，EPE 处理导致侵袭性 MPM 细胞系中的细胞周期停滞在 G2/M 期并增加细胞凋亡。此外，EPE 强烈限制了 MPM 癌细胞的侵袭和 MMP-7 的分泌。我们的原始数据提供了 EPE 在 MPM 治疗中的潜在抗侵袭作用的证据。