微小囊泡介导的肺动脉高压细胞通讯。

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning110122, China.

Curr Med Chem. 2021;28(23):4731-4741. doi: 10.2174/0929867328666201124152406.

BACKGROUND

Pulmonary arterial hypertension is one of the chronic diseases that affect human health. Microvesicles participate in the communication between cells by fusing with the recipient cells to transfer the bioactive molecules, such as lipids, proteins, RNA, etc., to the target cells. Microvesicles are involved in various biological processes and have the functions of regulating immunity, promoting angiogenesis, and so on. Microvesicles derived from various cells may become the diagnostic biomarkers or therapeutic targets for the diseases. Therefore, exploring the role of microvesicles-mediated cell communication has become a potential therapeutic target for pulmonary arterial hypertension.

OBJECTIVE

It is to clarify the classification, features, and mechanism of microvesicles in cell communication and to discuss the potentially important roles of microvesicles-mediated cell communication in pulmonary arterial hypertension.

RESULTS

Inflammation is an important pathogenesis of pulmonary arterial hypertension. Many studies have shown that microvesicles from different cells can participate in the pathological process of pulmonary arterial hypertension by transferring the inflammatory factors contained in them.

CONCLUSION

Microvesicles-mediated cell communication may become the therapeutic target for pulmonary arterial hypertension.

背景

肺动脉高压是影响人类健康的慢性疾病之一。微小囊泡通过与受体细胞融合来传递生物活性分子（如脂质、蛋白质、RNA 等），从而参与细胞间的通讯，这些微小囊泡参与各种生物学过程，并具有调节免疫、促进血管生成等功能。源自各种细胞的微小囊泡可能成为疾病的诊断生物标志物或治疗靶点。因此，探索微小囊泡介导的细胞通讯的作用已成为肺动脉高压的潜在治疗靶点。