Noguchi T, Adelaide J, Marics I, Raybaud F, de Lapeyrière O, Birnbaum D
Unité 119 de l'INSERM, Marseille, France.
Bull Cancer. 1987;74(6):607-21.
ras oncogenes are cellular genes altered by point mutation in 10 to 30% of human tumors. Under this mutated form they play a role in the malignant process, probably in association with other oncogenes. The different ras genes identified in human cancers, the point mutations that activate the ras genes and the properties of the ras proteins are described.
Ras癌基因是在10%至30%的人类肿瘤中因点突变而改变的细胞基因。在这种突变形式下,它们在恶性过程中发挥作用,可能与其他癌基因共同作用。文中描述了在人类癌症中鉴定出的不同Ras基因、激活Ras基因的点突变以及Ras蛋白的特性。