相似杂环化合物手性结晶的成败。
Success or Failure of Chiral Crystallization of Similar Heterocyclic Compounds.
机构信息
Department of Chemistry, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.
Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
出版信息
Molecules. 2020 Dec 2;25(23):5691. doi: 10.3390/molecules25235691.
Single crystals of two achiral and planar heterocyclic compounds, CHHO() and CHNO (), recrystallized from ethanol, were characterized by single crystal X-ray analysis, respectively, and chiral crystallization was observed only for as 222 (# 19), whereas it was not observed for 2/c (# 14). In , as a monohydrate, the hydrogen bonds were pronounced around the water of crystallization (O4), and the planar cyclic sites were arranged in parallel to slightly tilted positions. On the other hand, an anhydride formed a dimer by hydrogen bonds between adjacent molecules in the crystal, which were aggregated by van der Waals forces and placed in parallel planar cyclic sites.
两种非手性和平面杂环化合物 CHHO() 和 CHNO () 的单晶分别通过单晶 X 射线分析进行了表征，只有 作为 222 (# 19) 观察到手性结晶，而 2/c (# 14) 则没有观察到。在 中，作为一水合物，氢键在结晶水 (O4) 周围明显，平面环状位置平行排列但略有倾斜。另一方面，无水物 通过相邻分子之间的氢键形成二聚体，这些二聚体通过范德华力聚集并放置在平行的平面环状位置上。
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